ASTRA Therapeutics GmbH is a drug development company focused on creating novel therapeutics for parasitic diseases by targeting tubulin, a highly conserved protein essential for cell division. Through atomic-scale drug engineering, ASTRA has developed Parabulins, species-specific tubulin inhibitors that effectively target parasite tubulin while remaining harmless to host cells. The company is advancing Parabulins to address parasitic pathogens in human health, veterinary medicine, and agriculture.

ATLyphe AG is a biotech startup founded in July 2023, headquartered at Zürich ETH-Zentrum. It focuses on developing targeted immunotherapy for transplantation and cancer. The company's primary innovation is ALY117, a bispecific T cell engager designed to improve the conditioning process for hematopoietic stem cell transplantation (HSCT), particularly for acute myeloid leukemia (AML) patients. This agent aims to eliminate residual leukemic cells, prevent relapse, and prepare patients for transplantation, enhancing their chances of survival and making the treatment process more bearable.

Abologix Sàrl, a Geneva-based biopharmaceutical company founded in 2018, develops monoclonal antibody therapeutics targeting cancers with poor prognoses or resistance to standard treatments. Their lead program, H225, is designed to treat sub-types of non-Hodgkin's lymphoma, particularly Mantle Cell Lymphoma, by blocking Junction Adhesion Molecule C (JAM-C). Preclinical studies have shown that H225 treatment significantly increases overall survival. The company is also developing antibodies targeting Olfactomedin-like protein 3 (Olfml3), associated with tumor angiogenesis, aiming to create new-generation inhibitors for cancer treatment. The founding team includes Dr. Ignacio Faus, Prof. Beat Imhof, and Dr. Thomas Matthes.

Abrinca GmbH tackles a key bottleneck in microbial genomics research - complex data analysis - through its flagship product, OpenGenomeBrowser (OGB). This powerful, user-friendly platform streamlines data management and analysis, enabling researchers across sectors like food, pathology, agriculture, and waste management to work efficiently via a web browser. Whether hosted locally or in the cloud, OGB accelerates research workflows and enhances data utility. Abrinca supports its clients with flexible licensing, tailored training, consulting, and custom development to maximize the impact of microbial genomics.

Actival SA is a Swiss medtech startup based in Neuchâtel developing next-generation dental aligners that integrate oral hygiene functionality. A spin-off from CSEM, the company has created patented 3D-printed "Active Aligners" with microchannels that promote saliva flow and deliver antibacterial agents, fluoride, and customizable flavors - addressing common issues like plaque buildup and bad breath. Backed by CHF 150,000 from Venture Kick in December 2024, Actival plans to launch in Switzerland and the U.S. by late 2025, targeting dental clinics through a B2B model.

Adiposs, a clinical-stage biotech startup, specializes in medical imaging products and technologies. With over half of cancer patients not benefiting from costly immunotherapy treatments, Adiposs is creating ImageBAT, a first-in-class product that detects brown fat to predict immunotherapy outcomes. Administered as a drink before routine scans, ImageBAT offers a quick, non-invasive way to avoid ineffective treatments, streamlining the path to more effective cancer care and enhancing patient survival chances.

Recolony AG is a Swiss startup focused on developing microbiome-based therapies to combat colorectal cancer. By leveraging the power of beneficial bacteria, Recolony aims to create innovative treatments that can improve patient outcomes and provide a novel approach to cancer therapy. The company is at the intersection of microbiology and oncology, seeking to harness the potential of the human microbiome in fighting cancer.

Aerospec SA develops the Aerosol InfraRed (AIR) Monitor, a product designed to measure and analyze the chemical composition of particulate matter (PM) pollution. Their technology provides detailed data on pollution sources, empowering industries and governments to improve air quality and public health. With two patents, Aerospec is preparing to commercialize its product after successful pilot demonstrations, and they have gained interest potential customers, including academic institutions and public bodies.

Akina, a startup founded in 2021 by Florian Haufe and Michele Xiloyannis, develops AI-powered medical software for home physiotherapy. Using smart device webcams, its AI motion coach analyzes and guides patient movements in real time. Healthcare professionals can monitor and adjust patient therapies efficiently via a cloud portal. Originating from ETH Zurich, Akina's team specializes in movement science, AI, and rehabilitation technology.

Alithea Genomics emerged from a project aiming to make RNA sequencing more affordable and rapid. The company, co-founded by Riccardo Dainese, Daniel Alpern, and Prof. Bart Deplancke, developed the Bulk RNA Barcoding and Sequencing (BRB-seq) technology. Recognized for its innovation in a 2019 Genome Biology publication, the company offers BRB-seq based kits and services, responding to a significant industry demand.

Almer Technologies AG, founded in January 2021 and based in Bern, Switzerland, develops augmented reality (AR) glasses designed for long-term wear and hands-free operation. These glasses aim to enhance productivity in technical fields by offering features like lightweight design, extended battery life, and integration with personal eyeglass prescriptions. The company's innovative approach addresses limitations of current AR glasses, such as short battery life and heavy weight.

AlpinaSana AG, founded in June 2024 and based in Zurich, is dedicated to combating malnutrition, particularly among the elderly. The company offers an integrated solution that combines advanced software and patient-centric Foods for Special Medical Purposes (FSMP). Their software utilizes 3D imaging and artificial intelligence to detect malnutrition, streamlining caregiver efforts and reducing treatment costs by approximately CHF 600 per patient per day. This technology also enables hospitals to receive higher reimbursements for patient care. Additionally, AlpinaSana's FSMP products, such as meal drinks and nutritious ice creams, are designed to be both effective and appealing, and can be prescribed for up to two years post-discharge, enhancing patient well-being and compliance.

Amporin Pharmaceuticals AG, founded in Basel in 2024, is a biotech startup developing a novel class of small-molecule drugs aimed at protecting and repairing cell membranes. These oral treatments target over 50 degenerative diseases associated with protein misfolding and aggregation, such as Parkinson's disease and ALS, which collectively affect more than half a billion people and result in 3.6 million deaths annually. The founding team comprises industry veterans with over two decades of experience in neuroscience drug discovery and development.

Founded in 2022, Antefil introduces a cost-effective and environmentally friendly approach to producing lightweight structures for industrial applications, leveraging patent- pending technology that coats glass fibers with a meltable, recyclable plastic. This innovative method enables the creation of lightweight structures using just heat and minimal pressure, facilitating a shift towards more sustainable and efficient composite production at scale. Antefil has quickly gained recognition for its pioneering technology, including winning the ETH Zurich Spark Award among other accolades.

AtlasVR, an ETH Zurich spin-off, revolutionizes machine tool training with its virtual reality (VR) solutions, allowing for intuitive, anytime, anywhere learning without needing actual machinery. This method significantly cuts training costs and boosts trainee motivation and engagement. Focused on the B2B sector, particularly within the machine tool industry, AtlasVR AG provides a comprehensive solution, guiding customers from technology introduction and implementation to onsite rollout, with ongoing service maintenance options.

Augury Medical GmbH, founded in 2024, and headquartered in Biel, Switzerland, is a MedTech startup dedicated to enhancing the safety of cardiovascular disease treatments. Their flagship product, Pace Locator, is an innovative medical device that offers real-time, 3D visualization of cardiac electrical signals through compact, noninvasive technology. This advancement addresses current limitations in cardiac imaging, such as invasiveness, lack of three-dimensional capabilities, and delayed results. Clinically tested in two human trials, Pace Locator provides cardiologists with more precise visualization, thereby bolstering confidence in both diagnostic and surgical decisions. Augury Medical is actively working to bring this device to market, targeting multiple revenue channels within markets that present an annual revenue potential exceeding 500 million CHF.

Aukera Therapeutics GmbH is a biotech spin-off from the Biozentrum of the University of Basel, founded in October 2021. The company specializes in developing novel pharmaceutical drugs that target specific branches of the mTOR pathway, which plays a key role in regulating cell growth. Aukera’s discovery platform focuses on creating small molecule drugs for cancer and other mTOR-related conditions. Its technology aims to control mTORC1 activity, with potential applications in cancer therapy and beyond.

BTRY AG, a Swiss startup founded in 2023, is pioneering energy storage with its innovative solid-state batteries that can fully charge in just one minute. These batteries use a thin-film design, stacked to enhance both energy density and charging speed, and are customizable to meet different customer needs. BTRY’s environmentally friendly production process is solvent-free, reducing energy consumption and chemical waste. Recognized as a spin-off from ETH Zürich and Empa, the company has attracted significant support, including backing from Venture Kick​.

Bewelab SA, formerly Neuria SA, is a Swiss digital therapeutics startup developing evidence-based mobile games to help individuals rewire their brains, reduce unhealthy food cravings, and adopt healthier eating habits. Based on over 15 years of neuroscience research, its patented neurocognitive motor training system aims to provide scalable, clinically validated solutions for chronic diseases related to diet and weight management. Led by CEO Frédérik Plourde and CSO Lucas Spierer, Bewelab operates in the rapidly growing digital therapeutics market and has secured support from Venture Kick.

Biosimo AG is a Swiss startup founded in 2022, based at Zürich ETH-Hönggerberg. The company focuses on developing bio-based bulk chemicals, such as bio-acetic acid and acetyls, as sustainable alternatives to fossil materials. Their goal is to address the demand for greener consumer products and contribute to a sustainable future. Biosimo has received support from initiatives like Venture Kick and has been recognized in the TOP 100 Swiss Startup Award.

Borobotics GmbH, founded in July 2023 and headquartered in Winterthur, Switzerland, specializes in innovative geothermal drilling solutions. The company has developed an autonomous, energy-efficient drilling robot that operates directly within boreholes, significantly reducing construction costs and minimizing environmental impact. This technology addresses common challenges in geothermal energy extraction, such as high costs, noise, and landscape disruption, thereby enabling more buildings to utilize geothermal heating. Borobotics generates revenue by providing this drilling robot to companies worldwide, offering a comprehensive service that includes the drilled borehole and the geothermal probe.

Bottneuro is focused on providing custom devices for neurological care, combining digital biomarkers, brain imaging, and neuromodulation. They offer tailored tES devices for non-invasive brain stimulation and 3D printed EEGs for analyzing brainwave patterns, aiding in personalized treatment and early detection.

Carewell SA is a digital health startup based in Pully, addressing staffing shortages in the healthcare sector through an AI-powered platform that connects healthcare institutions with qualified professionals for flexible, short-term assignments. Founded in 2024, the company empowers care workers with greater autonomy while helping hospitals, clinics, and home care services fill urgent personnel gaps. Backed by Venture Kick and FIT, and winner of the 2025 PERL Trophy, Carewell is expanding across Switzerland to meet growing demand in a CHF 800 million market for temporary healthcare staffing.

CellX Biosolutions AG, a Swiss startup founded in 2024 and based in Zürich, develops innovative bacteria-based solutions to efficiently degrade industrial chemical pollutants. Using a novel microfluidic-based tool, the company captures and harnesses naturally occurring bacteria from remote environments to address pollution more sustainably and cost-effectively than conventional methods. Led by CEO Dr. Estelle Clerc and a multidisciplinary team, CellX Biosolutions has secured CHF 150,000 from Venture Kick to advance its technology, positioning itself within the rapidly growing $30 billion pollution treatment market.

CompagOs AG, a Swiss spin-off from ETH Zürich, specializes in personalized diagnostics for bone health. The company uses innovative 3D printing technology to produce mineralized and multicellular bone organoids called Bon3OID™. These organoids assist in drug discovery, preclinical patient stratification, predictive diagnostics, and personalized medicine. CompagOs offers products and services for various bone conditions including healthy bone, fractures, bone metastasis, osteosarcoma, osteogenesis imperfecta, and osteoporosis.

Correntics is a Swiss climate risk analysis provider that enables companies to predict and mitigate risks stemming from weather and climate extremes. Their Software-as-a-Service (SaaS) solution provides unique climate-risk analytics capabilities for enhancing internal risk management across industries such as agriculture, chemical, logistics, and finance. Additionally, Correntics collaborates with consulting firms to improve the efficiency and accuracy of physical climate risk assessments necessary for compliance with regulations like the Corporate Sustainability Reporting Directive (CSRD).

Cultivated Biosciences SA is a Swiss startup founded in December 2021 that focuses on developing creamy, dairy-free ingredients for alternative dairy products. The company aims to enhance the texture, mouthfeel, and nutritional value of plant-based dairy alternatives using a unique fat ingredient produced through fermentation. Their innovation addresses the common shortcomings of plant-based dairy products, aiming for a healthier and more sustainable option that closely mimics traditional dairy experiences.

Cowa Thermal Solutions AG, founded in May 2019 in Root D4, Switzerland, specializes in advanced thermal energy storage using phase change materials (PCM). Their Cowa COMPACT Cells offer high energy density and efficiency, enhancing heating and cooling systems' performance. With up to 75 kWh/m³ storage capacity, these compact, cost-effective, and environmentally friendly solutions support sustainable energy management. Designed for integration with heat pumps and photovoltaic systems, Cowa's technology aims for over 20 years of reliable service without capacity loss.

CustomSurg AG, founded in Zurich, Switzerland, develops AI-powered solutions for complex orthopedic surgeries. Their technology provides personalized surgical planning and patient-specific implants using data-driven biomechanical processes, enhancing the treatment of complex bone fractures. CustomSurg aims to transform subjective surgical approaches into objective, data-based practices, improving outcomes and reducing complications. The company's innovative solutions are backed by research from prestigious institutions and leverage advanced predictive analytics for optimal surgical strategies.

DAAV, an EPFL spin-off and previously known as Exomotion, develops the ALLURE electric wheelchair, enhancing mobility for individuals with disabilities. The chair offers advanced maneuverability with the ability to move in multiple directions, and includes an autonomous navigation system suitable for navigating complex environments such as airports. Focused on functionality and user autonomy, DAAV combines practical design with AI technology to improve mobility options for its users​.

DPhi Space Sàrl, founded in January 2024 and headquartered in Lausanne, Switzerland, is dedicated to advancing space infrastructure to support a spacefaring civilization. The company addresses the high costs and complexities of deploying assets into orbit by developing a shared satellite platform that increases payload capacity, reduces costs, and provides advanced in-orbit computing capabilities. This approach enables various entities to offer space-based services without the need for dedicated satellites. DPhi Space aims to democratize access to space, inviting hardware and software developers to utilize the abundance of sensors and computing power in orbit to create new applications that benefit humanity.

DeepPsy AG, based in Zurich, Switzerland, is a precision psychiatry startup founded in March 2022. They leverage advanced EEG and ECG analysis through proprietary medical software to predict responses to psychiatric treatments such as rTMS, psychotropics, and psychedelics. This approach aims to optimize treatment plans, reduce trial-and-error, and enable data-driven psychiatry for better patient outcomes. DeepPsy's high-quality, ISO13485 certified services support physicians, professionals, and researchers in understanding and utilizing neuro-biological data for personalized treatment strategies.

EVIIVE AG, founded in 2024 and based in Obfelden, Switzerland, is a biotech startup revolutionizing precision medicine through its advanced extracellular vesicle (EV) biomarker discovery platform. By combining single EV analysis and machine learning, EVIIVE enables early disease detection and personalized treatment strategies, enhancing diagnostic accuracy across various conditions. Supported by initiatives like Venture Kick and Venture Leaders Biotech, the company is poised to transform therapeutic approaches with its innovative, data-driven solutions.

FimmCyte AG, founded in 2022 and based in Basel, Switzerland, is developing the first disease-modifying treatment for endometriosis, a chronic condition affecting one in ten women. Unlike current palliative options with significant side effects, FimmCyte’s therapy has shown promise in eliminating endometriosis tissue in laboratory and animal models, with clinical trials planned. By addressing a significant unmet medical need, FimmCyte aims to reduce the healthcare and societal burdens of endometriosis and improve the lives of affected women.

Galventa AG, founded in 2018 and based in St. Gallen, Switzerland, is a life science company specializing in advanced galenic formulations for nutraceuticals and pharmaceuticals. Their flagship product, B·SYNC®, leverages patented technologies to optimize bioavailability and synchronize the body's natural rhythms. The company emphasizes scientific validation, conducting thorough human clinical trials to ensure the efficacy and safety of its products. Galventa's innovations aim to enhance consumer well-being by improving sleep and wakefulness naturally.

Grensol AG, founded in 2021 in Zurich, Switzerland, is a cleantech startup converting mixed plastic waste from vehicles and appliances into emission-free hydrogen and recovered carbon black using its patented photolysis process. With its first plant set to launch in Solothurn in early 2025, Grensol promotes a circular economy and CO₂ reduction. The company has secured over CHF 1.4 million in grants, including CHF 150,000 from Venture Kick, and is led by experts with experience at Glencore, UBS, BMW, and McKinsey.

HeroSupport SA, founded in June 2022 in Veyrier, Switzerland, specializes in personalized patient-positioning medical devices to enhance cancer treatment. Their initial product is a customized breast immobilization shell for prone breast radiotherapy. The company aims to develop additional devices for pediatric patients, leveraging 3D printing, imaging, and radiology technologies to improve treatment outcomes.

IMAI MedTech GmbH, founded in March 2024 and headquartered in Schlieren, Switzerland, is a medical technology startup focused on enhancing cancer diagnostics. Traditional 2D histopathology examines thin tissue slices, often leading to false-negative results due to limited sample analysis. IMAI MedTech addresses this issue by developing a platform that automates the processing of 3D tissue samples, enabling more accurate spatial imaging and analysis within two days. This approach aims to improve diagnostic precision, leading to better treatment decisions and patient outcomes. The company was co-founded by Dr. Francesca Catto (biomedicine), Dr. Robert Axelrod (life sciences), and Sascha Brun (robotic engineering).

Ionic Wind AG is a Swiss cleantech startup based in St. Gallen, pioneering a solid-state airflow technology that utilizes electrostatic principles to move air without mechanical fans. Their patented Ionic Wind Amplifier employs custom-designed needle electrodes and a flow-optimized housing to generate efficient, silent airflow, offering a compact and energy-saving alternative to traditional cooling systems. This innovation has the potential to reduce cooling energy consumption by up to 60% in data centers and high-performance electronics. Initially developed at Empa, the technology has been successfully applied in non-thermal drying processes and is now being adapted for broader applications, including air purification and cooling in extreme environments.

Irmos Technologies AG, founded in February 2023 as a spin-off from ETH Zurich, specializes in structural health monitoring to extend the operational lifespan of buildings and bridges. Their intelligent software solution enables owners of large infrastructure portfolios to predict and prioritize capital expenditures for structural maintenance, optimizing retrofit costs and preventing business downtimes without compromising safety. Structural engineers benefit from reduced uncertainties and can provide optimal solutions to their clients. Irmos's innovative solution has been deployed in multiple benchmark buildings and bridges, collaborating with leading engineering firms in Switzerland.

Isochronic offers advanced simultaneous pick & place robotic systems, enhancing industrial automation by handling multiple parts at once. This technology accelerates production in various sectors, meeting the growing demand for faster, more efficient manufacturing automation.

JOSEPHA is a Swiss startup developing an AI-powered shopping platform that consolidates product information - such as prices, reviews, tutorial videos, and offers - into a single, interactive interface. Addressing the inefficiencies of fragmented online searches, JOSEPHA streamlines the buying process for consumers by centralizing data that is typically scattered across multiple sources. The company was founded by Dr. Silvan Weder and Josef Gitterle, combining expertise in AI and commerce.

Kidemis AG is a Swiss food/feed tech company founded in June 2023, based in Zollikofen. The company specializes in converting low-value sidestreams into high-quality mycoprotein using mycelium-based fermentation. Their primary focus is on providing sustainable and nutritious protein solutions for the aquaculture industry. Kidemis leverages proprietary technology to offer cost-effective and environmentally friendly alternatives. Their innovative approach addresses the demand for sustainable seafood and aims to reduce food waste.

Lighthouse Tech SA, founded in November 2020 and headquartered in Morbio Inferiore, Switzerland, is dedicated to enhancing mobility and independence for blind and visually impaired individuals. Their flagship product, TAMI®, is a stylish electronic eyewear frame designed to complement the traditional white cane by detecting obstacles above waist level, thereby offering full-body protection from collisions. Available in various styles and colors, TAMI® aims to reduce the social stigma often associated with assistive devices.

Luya Foods AG, founded in July 2021 and based in Bern, specializes in creating alternative protein foods using organic, naturally fermented ingredients. Their innovative products are made from okara, a by-product of tofu and soymilk production, and chickpeas, offering nutritious and flavorful options without additives. Leveraging circular fermentation technology, Luya Foods aims to reduce food waste and deliver versatile food options. They have gained traction among chefs and consumers with applications ranging from BBQ skewers to curries and nuggets.

Splint Invest is an innovative app platform designed to democratize access to alternative investments by offering digital shares, known as Splints, in physical assets. This approach allows individuals to co-own parts of valuable items like whiskey barrels or luxury watches with investments starting from as little as EUR 50, making alternative investments accessible to a broader audience beyond the traditionally wealthy investors.

NXI Therapeutics AG, founded in May 2021 and headquartered in Basel, Switzerland, focuses on developing novel therapies for autoimmune diseases and organ transplantation. The company aims to advance compounds that inhibit coronin 1-dependent T cell activation. They are also working on a biomarker and diagnostic program to evaluate therapy effectiveness and analyze naive T cell populations in immunosuppressed patients. NXI Therapeutics operates in the biotech sector, particularly in drug discovery and small molecule drugs.

NaturLoop, a spin-off from the Bern University of Applied Sciences (Institute for Materials and Wood Technology), specializes in engineering biocomposites and developing the technology needed for their production on an industrial scale. The company has created Cocoboard®, an innovative material designed for use in furniture and construction. NaturLoop is in the process of opening its inaugural Cocoboard® factory in the Philippines, where it will convert agricultural by-products like coconut husks into sustainable biocomposites using a proprietary bio-based adhesive.

Neology Hydrogen SA, founded in March 2023, focuses on carbon-free energy solutions for commercial transportation, particularly heavy-duty vehicles. The company uses ammonia as an energy carrier due to its high volumetric energy density, long storage capability, and compatibility with existing infrastructure. Neology is developing a thermochemical ammonia cracking device to transform ammonia into hydrogen for fuel cells, aiming to utilize ammonia as a future carbon-free energy carrier. The company is headquartered in Lutry, Switzerland.

Nerai Bioscience develops AI-assisted genome editing tools that overcome the limitations of current CRISPR-Cas9 technologies. Its fully automated protein engineering platform generates next-generation genome editors with improved targeting range, efficiency, specificity, and safety. Initially focused on liver and eye diseases such as alpha-1 antitrypsin deficiency and phenylketonuria, Nerai is advancing its technology from academic validation toward commercial application, supported by an Innosuisse grant and strategic industry collaborations.

Neurosoft Bioelectronics is committed to enhancing patient care for individuals with neurological disorders. Their efforts are centered around the development of soft implantable electrodes designed to interface with the nervous system. Neurosoft Bioelectronics has innovated a proprietary technology enabling the creation of highly adaptable neural interfaces, facilitating sustained integration within the body. These advancements aim to improve therapeutic efficacy for patients and explore new possibilities in neural interface applications previously considered unattainable.

NexMR AG is a biotech startup that specializes in high-throughput screening for drug discovery using Nuclear Magnetic Resonance (NMR) technology. Founded in May 2022 and headquartered in Schlieren, Switzerland, NexMR's proprietary technology enables rapid screening of thousands of molecules and characterizes hits with minimal assay development. Their approach, which uses milder, more physiologically relevant conditions than other techniques, aims to accelerate the drug discovery process by providing fully characterized hits that support pharmaceutical pipelines.

NovoViz SA specializes in designing and manufacturing single-photon processing detectors for computational imaging. Their technology is geared towards applications that require high sensitivity and speed but need to manage smaller data volumes. With a focus on reducing the complexity and cost of experimental setups, NovoViz's solutions are designed for fields such as quantum imaging and machine vision. Backed by over a decade of research and two patent applications, the company aims to make single-photon technology more accessible and practical for everyday use​.

Oncobit, a MedTech spin-off from the University of Zurich, focuses on developing precision diagnostic and monitoring solutions to support personalized cancer therapies. Their approach integrates technical expertise, proprietary software, and clinical collaborations, aiming to enhance the sensitivity and comprehensiveness of tests, initially targeting melanoma with potential expansion to other cancer types. Through collaborations with cancer centers in Europe and the US, Oncobit seeks to contribute to improved patient care by facilitating the adoption of tailored treatments within the medical community.

Orio Therapeutics SA, founded in February 2023, is a biotech startup based in Monthey, Switzerland. The company has developed a drug-delivery platform based on protein engineering, which has shown efficacy in animal models for skin, bone, skeletal muscle, and cardiac muscle regeneration. Initially focusing on acute myocardial infarction treatment, Orio Therapeutics aims to enter clinical trials by 2025. The technology can be applied to various protein therapeutics requiring localized action, and the company is seeking investment to advance its pre-clinical trials.

Palto Therapeutics AG, founded in December 2020, is a Swiss biotech company specializing in RNA-based therapies. Their key innovation, SmartCoat, is a nano-structure designed to improve the delivery and targeting of small interfering RNA (siRNA) therapies. SmartCoat protects siRNA from degradation, enhances pharmacokinetics, and enables precise targeting of cells and organs without causing an immune response. The company focuses on drug discovery, cancer therapies, and nanotechnology solutions.

Perovskia Solar AG, a Swiss cleantech startup, provides digitally printed, customizable solar cells for OEMs. Their technology integrates into electronic devices and sensors, performing efficiently even in low-light conditions. An example is the BHeart by Baracoda, which won the CES Innovation Award for sustainability. Since its inception, Perovskia Solar has acquired 15 paying customers, showing strong market acceptance.

Planeto SA specializes in the digital design of climate-neutral district heating networks. Their key product, the Thermal Energy System Simulation Assistant (TESSA), is a user-friendly, web-based software that optimizes the planning of heat and cold networks. TESSA provides quick, place-specific solutions to streamline and enhance district energy planning, making the process faster, more efficient, and cost-effective. Planeto's goal is to support the expansion of sustainable energy systems across Switzerland and beyond.

Procavea Biotech AG is revolutionizing the delivery of RNA therapeutics and small molecule drugs with its first-in-class protein-based delivery platform for oligonucleotides and small molecules. Developed at ETH Zurich and protected by two patents, the technology addresses the growing demand for innovative delivery solutions in the Antisense and RNAi therapeutics market. Procavea collaborates with pharmaceutical companies, providing bespoke delivery systems through strategic partnerships, enabling them to gain a competitive edge. In the long term, the company aims to develop its own therapeutic pipeline, driving forward advancements in precision medicine.

RTDT Laboratories AG, founded in May 2022 and headquartered at ETH-Hönggerberg in Zurich, is a deep tech company specializing in structural health monitoring and power performance optimization for wind turbines. Leveraging research from ETH Zurich, RTDT integrates real-time digital twins of wind turbines with a comprehensive analytical library of physics-based AI models. This integration, delivered through their SaaS platform, addresses a wide range of use cases holistically. Additionally, RTDT has developed Aerosense, a wireless, self-sufficient sensor module that captures aerodynamic, vibrational, and acoustic data directly from turbine blades.

Rematter AG, founded in May 2022 and based in Rotkreuz, Switzerland, develops sustainable earth-timber floor slabs as an eco-friendly alternative to traditional reinforced concrete floors. Using robotic prefabrication, its slabs ensure high quality, cost efficiency, and improved indoor climate while helping builders meet sustainability regulations. Operating at the intersection of proptech, cleantech, materials, and robotics, Rematter provides architects, engineers, and developers with an innovative solution for sustainable construction.

Resmonics, a spin-off from ETH Zurich, specializes in ambient Edge AI to enhance infection control in healthcare facilities. Their pioneering system, developed over seven years with leading Swiss institutions, uses patented acoustic AI to detect lung symptoms and environmental sensors to monitor indoor spaces. This integration not only improves staff compliance with hygiene policies by up to 15 times but also delivers a 500% ROI for hospitals by significantly reducing sick leave, not accounting for further savings from reduced staffing needs and prevented business losses.

Rhovica Neuroimaging develops the SoNav System, a patented technology designed to improve emergency treatment for patients with elevated intracranial pressure due to conditions like severe head trauma or brain bleeding. The system enables precise, navigated placement of brain catheters (EVDs) and real-time bedside monitoring in emergency rooms and intensive care units, aiming to set a new standard for fast, safe, and cost-efficient neurocritical care.

RoBoa develops a bio-inspired, snake-like robot capable of autonomously navigating extreme confined spaces using growing-based locomotion. Designed to access areas that are unreachable for humans or conventional robots, it collects critical maintenance data to minimize downtime and enhance safety in industries such as wastewater, chemicals, power, and oil and gas. Founded by ETH Zurich engineers, RoBoa also serves search and rescue missions, locating and aiding victims in disaster zones.

SPEQQLE SA develops RefFIT, software for analyzing spectroscopic data in material science. It helps industries like manufacturing, semiconductors, and photonics with product development, quality control, and sorting. By leveraging machine learning techniques, the platform provides a no-code, model-based solution that reduces calibration time, making spectroscopic analysis faster, more accurate, and accessible. This innovative software simplifies complex data analysis, enabling new applications in material science. Founded in May 2024, SPEQQLE focuses on high-tech sectors such as materials, AI, and SaaS.

Founded in 2023 as an EPFL spin-off and based in Renens, SUNAXER develops next-generation receivers for concentrated solar collectors to accelerate the transition to renewable industrial heat. With industrial heat responsible for 20% of global carbon emissions, SUNAXER addresses this challenge by providing high-performance receivers coated with an innovative selective absorber layer. Their patented, energy- and cost-efficient manufacturing process ensures superior durability and optical efficiency, positioning the company as the preferred supplier for solar process heat system manufacturers.

Scanvio Medical develops AI-powered software that enables standard ultrasound devices to detect endometriosis with expert-level precision, significantly reducing the typical diagnostic delay from up to 12 years to as little as 1–3 years. The solution offers real-time anatomical guidance and labeling, making non-invasive diagnosis broadly accessible. The founding team brings together leading AI and ultrasound researchers, clinical experts, and a seasoned MedTech entrepreneur.

School Rebound has developed the Dynamilis iPad application, designed to enhance children's handwriting skills. The app offers a comprehensive analysis of handwriting, identifying areas for improvement, and provides tailored activities developed in collaboration with over 40 handwriting specialists. These activities, presented as games, are intended to make learning engaging and effective, whether at home, with a therapist, or at school. Dynamilis offers subscription plans tailored for parents, therapists, and schools, with access to content available in multiple languages including French, Italian, German, and English.

Seprify, formerly Impossible Materials, offers plant-based formulation ingredients, providing a sustainable alternative to the carcinogenic titanium dioxide. Initially targeting the food, pharma, and cosmetic sectors, its cellulose white pigment is ideal for plant-based products and has expansion potential in paint, coatings, and inks. Seprify's process also promises significant CO2 emissions reduction at scale.

Shape Biopharmaceuticals is developing SHAPEnano particles, a novel platform that enables patients’ own immune systems to produce therapeutic antibodies in vivo. This approach offers major advantages over conventional antibody therapies, including significantly reduced dosing frequency, elimination of anti-drug antibody responses, and lower production costs. Targeting large, underserved markets with blockbuster potential, Shape combines deep expertise in immunobiology, chemistry, and computational design to create next-generation immunotherapies. The founding team brings extensive experience from biotech ventures to global pharmaceutical companies.

SoHHytec, an EPFL spin-off, is a provider of innovative energy solutions that develops, builds, and operates Gardens and Forests of its proprietary Arbs (Artificial Trees) while offering Hydrogen and power as a service. Utilizing a patented photo-electrochemical technology, SoHHytec's product, the "Arb," mimics the function of real trees. It exclusively uses sunlight and water as inputs to simultaneously produce hydrogen (fuel), oxygen, and power (electricity and heat) on the same site, efficiently using minimal ground or roof space. Their integrated system achieves high solar-to-fuel and solar-to-electricity conversion efficiencies, operates at exceptional power and current densities, and provides cost-effective fuel and power production.

SolidWatts is a technology startup founded in October 2022, headquartered in Pully, Switzerland. It focuses on developing high-efficiency electric heating solutions for industrial processes that currently rely on fossil fuels. Their innovative Solid State Power Amplifier technology offers unprecedented power and efficiency, aiming to revolutionize industrial heating by making it cleaner and more sustainable. The company operates in the cleantech, energy efficiency, and renewable energy sectors.

SurgeonsLab AG, founded in March 2021 and based in Bern, Switzerland, creates patient-specific surgical training models using real medical images. Their platforms, such as SurgTrain™ and CathTrain™, offer high-fidelity simulations for neurosurgery and interventional radiology. These models enhance surgical skills through realistic practice, pre-operative planning, and validation of medical devices, ultimately improving patient outcomes. SurgeonsLab emphasizes precision, safety, and personalized medicine in their innovative training solutions.

Tandem develops precision therapeutics that target the disease-associated extracellular matrix - a key but often overlooked contributor to therapeutic resistance and poor outcomes in fibrotic tumors and organ fibrosis. By leveraging evolutionarily optimized peptides, the company aims to decode matrix-disease biology and overcome drug delivery barriers, ultimately improving treatment safety and efficacy for patients suffering from fibrotic conditions.

Tethys Robotics AG, a 2018 ETH Zurich spin-off, develops advanced underwater drones for challenging aquatic environments. Their flagship product, Tethys ONE, operates as both an ROV and AUV, performing precise inspections and surveys in turbid waters, currents up to 3.5 knots, and depths of 300 meters. Serving industries like hydropower, offshore wind, and search and rescue, Tethys ONE enhances safety and efficiency by reducing reliance on divers. Headquartered in Zurich, the company launched Tethys ONE globally in 2024, supported by organizations such as Venture Kick and ETH Zurich.

Transcality AG is a Swiss startup that builds virtual traffic replicas to aid in sustainable urban planning. Utilizing big data, cloud computing, machine learning, and simulation, Transcality develops digital twins of transportation networks, offering faster, cost-effective, and efficient models. These solutions help public authorities and engineering firms optimize transportation planning, reduce emissions, and contribute to a more sustainable future. Founded in 2022 at ETH Zurich, Transcality is focused on creating innovative tools for modern transportation challenges.

Vamoz AG is a Swiss tech startup that facilitates remote work abroad for employees. The company offers a web-based application where employees can request to work from different locations, and HR can manage these requests by assessing legal and business risks. The solution helps companies maintain oversight of their workforce while offering remote work as a non-monetary benefit to attract and retain talent. Vamoz AG was founded in November 2022 and is headquartered in Zurich.

Verretex SA is a Swiss cleantech startup based at EPFL Innovation Park, pioneering the regeneration of high-performance glass fiber textiles from 100% recycled fiberglass. Spun out of EPFL and INSA de Lyon research, Verretex has developed a proprietary process that restores recycled fibers to virgin-like quality, making them suitable for demanding applications in construction, automotive, marine, energy, and more. By turning composite waste into valuable materials, the company promotes circularity in the composites industry.

WasteFlow SA, founded in June 2024 and based in Lausanne, Switzerland, develops AI-powered vision systems to improve recycling processes. By integrating these systems into existing machinery, WasteFlow aims to enhance sorting efficiency and address challenges in recycling operations. Their SaaS platform provides real-time performance insights and machine adjustments to optimize energy use and increase recycling rates. The company was founded by EPFL and ETH Zurich alumni with expertise in computer vision and industrial product development. Their SaaS platform targets a total addressable market of CHF 5 billion, offering real-time key performance indicators and dynamic machine settings to simplify operations, enhance energy efficiency, and increase recycling rates.

WattAnyWhere offers a groundbreaking solution to the lengthy and costly process of connecting to the power grid for outputs of 300kW or more, through its Bioenergy-On-Demand fuel cell system. Developed in partnership with EPFL, HES- SO, and industrial collaborators, this off-grid, pollutant-free system utilizes renewable ethanol—a safe and economical liquid hydrogen carrier—to generate high-power, clean electricity. As the transition from conventional vehicles accelerates, WattAnyWhere's innovative approach repurposes surplus ethanol to support the growth of electric mobility.

a-metal offers an affordable, compact, and safe metal 3D printing machine designed for small and medium-sized enterprises, educational institutions, and development groups. Founded in March 2023 and based in Zurich, the company targets sectors like automotive, aviation, education, and medtech. Their system features a closed-loop powder handling cartridge, ensuring clean and safe operation without requiring specialized facilities or expertise.

askEarth AG is a Swiss startup founded in January 2023 and based in Zürich. It specializes in using satellite imagery and AI to predict environmental changes. As a spin-off from UZH, ETH, and EPFL, askEarth has secured a research and development project with the European Space Agency and has already acquired two paying customers in the geospatial intelligence market. The company aims to expand its team to meet increasing demand and to attract international clients.

Biped Robotics SA has developed the world’s first AI-powered navigation device for blind and visually impaired individuals. The device, worn like a harness, uses 3D cameras to detect and predict the movement of surrounding objects, providing intuitive audio feedback through bone conduction headphones. With over 250 beta-testers and 10 partners across Europe and the US, Biped launched its product in January 2023 and continues to expand.

CondenZero AG, a University of Zurich spin-off, is revolutionizing cryo-electron microscopy with its cutting-edge cryo-technology. Their innovation allows material scientists, life scientists, and nanotechnologists to conduct atomic-scale research at ultra-low temperatures of 5K within just one minute, with a hold time of up to 24 hours. This represents a significant improvement over traditional systems, which typically operate at higher temperatures with shorter hold times. CondenZero's technology has already been adopted by renowned research institutions, positioning it as a key player in advancing molecular-level research.

Flowbone SA, established in July 2020 and based in Lausanne, Switzerland, is a medtech startup developing innovative biomaterials for minimally invasive bone augmentation. Their flagship product is an injectable "bone-seeding" gel designed to locally strengthen fragile bones by initiating the body's natural mineral deposition, transforming into strong bone. This technology addresses osteoporosis-related fracture risks by providing a fast-acting treatment. Flowbone's solutions comply with bone biology, ensuring no interference with vascularization or mechanics, and the company is in the pre-clinical phase, preparing for clinical trials.

Matriq's patented DynamicMold technology innovatively embeds unique, machine-readable watermark codes into plastic components during their primary forming process. This method, which also incorporates optical security structures, aims to replace traditional labeling and laser marking in the medtech, automotive, and industrial sectors. It offers lower costs, faster production, reduced complexity, and enhanced anti-counterfeiting measures. Matriq's solution is ideal for high-volume markets with an increasing demand for sophisticated product marking, serving purposes like track and trace, identity verification, and brand trust.

MetaLead Therapeutics AG is a Swiss biotech company focused on developing next-generation medications to treat metal-related diseases, particularly lead poisoning and Wilson’s disease. Their platform technology is based on short peptides that bind tightly and selectively to toxic metal ions, facilitating their safe expulsion from the body. MetaLead is currently advancing treatments for Wilson’s disease, a genetic disorder that leads to harmful copper accumulation in the liver and brain. Their innovative approach, validated in animal models for lead poisoning, offers improved safety and efficacy compared to existing treatments.

qCella AG, founded in September 2023 and headquartered in Zürich, specializes in developing innovative heating solutions using their patent-pending copper-infused cellulose fiber hybrid material. This technology enables the creation of flexible, paper-thin heating mats that can be customized into various shapes and sizes. These mats provide uniform heating across their entire surface, eliminating the need for additional heat-distributing layers and enhancing energy efficiency. Their versatility allows integration into products such as heated seats for vehicles and aircraft, clothing, footwear, pain-relief devices, and machinery components.

viboo AG, founded in March 2022 and headquartered in Dübendorf, Switzerland, offers a cloud platform that connects to IoT devices in light commercial and multi-family buildings to enhance operational efficiency through AI-driven methods, notably Self-Learning Predictive Control. Developed from five years of research at Empa and ETH Zurich, their core algorithm can reduce heating energy consumption by up to 40% compared to industry-standard solutions while improving occupant comfort. The viboo cockpit, a Building Management System (BMS) for operators, provides insights into energy and comfort performance, conducts real-time data-driven system health analyses, and facilitates seamless operation of existing buildings. The team comprises experts in building automation, experienced software engineers, and professionals from the real estate sector.